What is NAD+ and why is it important?

What is NAD+?

Nicotinamide adenine dinucleotide (NAD+) is a molecule, which is present in all human cells. And plays a vital role in the regulation of several biochemical reactions. For example, regulating signaling pathways, DNA repair, metabolism, cellular processes, and ageing. The research has found that when there is an increase in cellular energy levels, the NAD+ levels also increase. This cellular energy provides fuel for your life. And gives power to your brain, heart, protects against DNA damage, which can increase your longevity.

One more study has depicted that this molecule is also used to power metabolism and enable mitochondria (a power station of the cell), which converts food into energy that is used to sustain your all body functions. On the other hand, a decline in NAD+ levels impairs your body’s ability to synthesis cellular energy that is significant in promoting protection against DNA damage.

In your body, this molecule is produced by simple amino acids. Like tryptophan, food that contains nicotinic acid (NA), nicotinamide mononucleotide (NMN), nicotinamide riboside (NR), and other precursors of NAD+.

NAD+ Levels decrease when we age

Why do we age?

The research has shown that decline in NAD+ levels is the major contributor to ageing. There is a dramatic reduction in NAD+ in your skin (almost 50% decline) when you age.

Two more studies use MRI to determine the NAD+ age-related decline in the human brain. The first research, which is conducted in 2015, has shown that there is a clear decline in the intracellular NAD+ levels. And redox state in the brain like with ageing. The second research conducted in 2019 depicted that between the period of adulthood and old age there to 10 to 25% reduction in NAD+ levels in the human brain.

“The loss of NAD as we age, and the resulting decline in sirtuin activity, is thought to be a primary reason our bodies develop diseases when we are old but not when we are young.”

Why do NAD+ levels decline with age?

According to both animal and human studies. It is clear that NAD+ levels decrease with growing ages in blood and several tissues. But why does its level decline? There are several mechanisms, which have the potential to reduce these levels. Including sedentary lifestyle, stress, overconsumption, DNA damage, and illness.

A better understanding of NAD+

According to health experts, at a young age, there is a healthy supply in your body. Which keeps you vibrant, young, and maintains good health. This is because it gives a direct link between your cellular signaling and metabolism. Furthermore, it plays a crucial role in supporting your immune system, regulating the sleep cycle, and repairing DNA damage.

When the natural level of NAD+ decreases, your longevity also decreases. Low levels also increase the risk of several chronic diseases and make visible signs of ageing more prominent. But don’t worry! By focusing on natural steps you can easily boost your NAD+ levels every day. In return, this increase in NAD+ level promotes your overall health, physical energy, and youthful metabolism.

Nicotinamide-adenine-dinucleotide molecule science image

Tips to boost NAD+ levels to increase longevity

The more effective way to maintain adequate levels of NAD+ is to make required lifestyle changes. By following these changes in daily life you can make your NAD+ levels strong. And can maintain high energy levels and healthy metabolism. Read more about how to increase NAD+ naturally.

Image of how to boost NAD with exercise


The research has shown that physical activity is the most efficient and easiest way to enhance your NAD+ levels and maintain overall wellbeing. In addition to a healthy weight and making you strong, exercise also boosts the DNA-rebuilding protein in the human body.

Daily exercise demands more NAD+ to produce energy, and the human body responds by synthesizing it. That’s why staying active can go a long way toward slowing down the progression of ageing.

Image of how to boost NAD+ with dietary changes

Dietary changes

Natural and organic foods that contain vitamin B including avocados, peanuts, and steamed fish should be a compulsory part of your daily diet.

The intake of more fermented drinks and foods such as kombucha and sauerkraut can also boost your NAD+ levels. Also, prefer whole grains as compared to processed products including white flour, rice, and bread because they are rich in B vitamins.

Image of how to boost Nicotinamide-adenine-dinucleotide by avoiding sun exposure

Avoid excessive sun exposure

If you spend more time in the sun, then you might be depleting your natural NAD+ supply in the body. This is because direct sunlight on the skin forces your body to use more amount of NAD+ to repair cell damage, which is caused by the sun’s UV (ultraviolet) rays.

So, when you are outside, avoid excessive sun exposure and try to cover your exposed skin with lightweight clothing, and loose-fitting to avoid skin damage.

Image of how to boost levels by seeking the heat

Seek the heat

Although long-term sun exposure is not good for NAD+ levels. And overall health, spending more time in artificial or natural heat can boost those levels. Heat sources including saunas, heated pools, and hot tubes can make your heart pump faster. And demands more energy from the body to keep cool. This situation stimulates the production of NAD+ to supply the required energy.

Image of how to boost NAD+ by supplementing with NMN

Supplementing with NMN

The use of Nicotinamide Mononucleotide (NMN) supplements is the quickest way to produce NAD+ in your body. In addition to NAD+ production, they also provide anti-ageing benefits to the human body.

These supplements contribute to cell energy and help your body cells to repair and regenerate. The intake of NMN along with NAD+ can promote your cell metabolism and improve insulin. NMN also works to prevent several metabolic conditions including obesity, diabetes, and fatty liver disease.