Quercetin is a natural dietary flavonoid that helps alleviate the aging process and chronic diseases in humans. Similarly, its antiviral features are noted by researchers via numerous scientific studies. In-vitro and silico studies demonstrate that quercetin interferes with coronavirus entry & replication cycle. This includes different stages like 3CLpro, NTPase/helicase, & PLpro. Let's dive in the Quercetin Covid Recovery Studies and facts.
This flavonoid is an ideal candidate for future and existing clinical trials against infections induced by the coronavirus. This happens due to the absence of pervasive toxicity and presence of pleiotropic activities. Research suggests that quercetin’s pairing with vitamins D or C exerts an antiviral action, thus functioning as a preventive/therapeutic add-on.
Quercetin covid recovery protocol helps induce immunomodulatory properties on COVID-19 patients.
To date, scientific research and study continue on the latest therapeutic and preventive strategies to tackle COVID-19 symptoms. No curative treatment is available for COVID-19, given that the virus is fairly new with fast mutation. Today, pharmaceutical companies are focusing on the creation of effective vaccination. However, wild and ancient anti-inflammatory & antiviral drugs have also surfaced as an alternative.
COVID-19 affects nasopharyngeal cells and different tissues and such as:
- Vascular Endothelium
- Nervous System
Treatment of Acute Inflammatory Pneumonia with Quercetin
SARS-CoV-2 causes acute cases of inflammatory pneumonia with excessive inflammation as an immediate risk. As per reports, the occurrence of cytokine storms can lead to death in COVID patients.
Some consequences of cytokine storms and severe inflammation include:
- Acute Respiratory Distress
- Multiple Organ Dysfunction
- Acute Long Injury
Certain phylogenetic findings denote similarities between the SARS-CoV-2 virus & bat coronavirus. Quercetin is found in abundance in fruits and vegetables.
Inflammasomes are multi-protein cytosolic complexes that assemble responding to cytosolic DAMPs and PAMP. The prime function of inflammasomes is the generation of active cytokines IL-18 and IL-1β. Inhibition or activation of the inflammasome is directly co-related to regulators like SIRT1, TXNIP, & NRF2. In this instance, Quercetin suppresses inflammasome by acting on these regulators.
Quercetin serves as an anti-oxidant, anti-inflammatory, analgesic, & inflammatory compound. Simply put, this compound is a potential COVID-19 treatment for the reduction of severe inflammation. It helps regulate symptoms in life-threatening conditions such as COVID-19.
Epidemiological evidence determines that Quercetin can reduce brain or cardiovascular diseases. Quercetin’s neuroprotective effects stem from its free-radical removal ability and anti-oxidant capacity. Quercetin supplementation for COVID-19 patients positively affects important bodily activities like:
- Energy production
- Mitochondrial biogenesis
- ROD production
- Electron transportation chain
- Mitochondrial defect correction
Moreover, quercetin also surpasses the blood and brain barrier.
TXNIP Quercetin COVID Recovery for Oxidative Stress
Trx (Thioredoxin molecule) paired with TrxR (Thioredoxin reductase) & NADPH binds to form the TrxR/Trx complex. It plays a prime role in several intracellular activities and regulates the body’s Redox system. Moreover, Trx/TrxR complex also affects intracellular activities like:
- Anti-oxidant and oxidant balance
- Apoptotic/functional/phenotypic homeostasis of cancer and immune cells
Similarly, TXNIP is closely associated with the NLRP3 inflammasome for activation in a ROS-dependent manner. This happens post-separation from Trx. TXNIP is the prime mediator of any dysfunction in pancreatic beta cells. This compound inhibits the body’s glucose uptake. Moreover, it also promotes caspase-1 cleavage that leads to beta cells death pending glucose dependence.
Quercetin COVID Recovery: Role of Vitamin C & Viral Infections
Several pieces of literature and scientific studies support quercetin’s antiviral properties. It is evident in in-vivo and in-vitro experiments. The flavonoid inhibits several cultured cell-based respiratory viruses. It also inhibits cytopathic effects induced by serotypes such as echovirus, rhinovirus, coxsackievirus, & poliovirus.
Quercetin significantly reduces any type of plaque formation caused by DNA and RNA viruses. Quercetin has the ability to block the virus’s entry or inhibit the enzymes responsible for viral replication. In-vivo research indicates that lethal meningoencephalitis viral infection can be deterred with quercetin. However, the effects of the same are dose-dependent. These benefits are negated when quercetin is given less than 3 days, through subcutaneous injection, or once/day.
Quercetin COVID recovery also displays immunocompetent effects with reduced organ damage severity. Patients given a dosage of quercetin get in and out protection from infection in the upper respiratory tract. This has no relation to immunomodulation.
In this instance, quercetin paired with vitamin C displays beneficial effects related to immune functions. Patients tested with viral contagion report reduced ascorbate levels when facilitated with vitamin C and quercetin. It also helps tackle COVID-related secondary systems like sepsis, ARDS, & other illnesses. As the infection spreads, vitamin C serves as an essential element for killing the neutrophil. It is ideal for phagocytosis promotion & apoptosis of used neutrophils.
Co-administration of vitamin C and quercetin along with vitamin B3 improved the survival rate. The researched rates are better than studies conducted for treatment via vitamin B3 & C devoid of quercetin. A clinical trial confirms that combining ascorbic acid and flavonoids in a 1:1 ratio reduces respiratory infections.
Quercetin in Virus Entry Inhibition
The most important step in viral infection in the human body is its entry. Clinical research for quercetin COVID recovery targets the study of this entry pattern to introduce a feasible antiviral treatment. Quercetin also demonstrates the capability of reduced cellular changes post-infection within 48 hours. This effect is only observed if quercetin is administered between 0 to 2 hours of viral entry.
The observed effect maximizes when administered at the soonest. Quercetin metabolites, when orally administered, promote increased survival. Depending on the dosage of quercetin (10/20/40mg), the chances of survival increase by 30 to 50 percent. Quercetin aids in the complete prevention of viral replication when introduced in the body within 2 hours.
Thus, quercetin plays a crucial role as a possible inhibitor of COVID-19 viral infection.
It is never too late to be prepared for the worst-case scenario. With Quercetin capsules, you can keep your body at its optimum state to fight off possible COVID-19 infection. Moreover, this flavonoid will help your cardiovascular health and boost natural anti-inflammatory action. So, why wait? Check out our Purovitalis Liposomal Quercetin supplement. The time is to act now and take charge of your health!