{"id":136724,"date":"2024-12-16T13:09:03","date_gmt":"2024-12-16T12:09:03","guid":{"rendered":"https:\/\/purovitalis.com\/?p=136724"},"modified":"2025-07-15T16:29:35","modified_gmt":"2025-07-15T15:29:35","slug":"clinical-research-reveals-nmns-effect-on-metabolism","status":"publish","type":"post","link":"https:\/\/purovitalis.com\/ro\/clinical-research-reveals-nmns-effect-on-metabolism\/","title":{"rendered":"Cercet\u0103rile clinice arat\u0103: efectul NMN asupra metabolismului"},"content":{"rendered":"<p class=\"wp-block-paragraph\">Cum se poate <a href=\"https:\/\/purovitalis.com\/ro\/produse\/nmn-capsule-lipozomale\/\">NMN<\/a> Cum poate NMN s\u0103 contribuie la \u00eembun\u0103t\u0103\u021birea s\u0103n\u0103t\u0103\u021bii metabolice? O echip\u0103 de cercet\u0103tori de la Facultatea de Medicin\u0103 a Universit\u0103\u021bii Washington din St. Louis a analizat acest subiect \u00eentr-un <a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC8550608\/\">studiu clinic<\/a> publicat \u00een revista <em>\u0218tiin\u021b\u0103<\/em>. Studiul se concentreaz\u0103 pe poten\u021bialul NMN de a \u00eembun\u0103t\u0103\u021bi metabolismul la femeile aflate \u00een postmenopauz\u0103, cu v\u00e2rste cuprinse \u00eentre 55 \u0219i 75 de ani, care sufer\u0103 de prediabet.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-background-of-the-study\">Contextul studiului<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">\u00cemb\u0103tr\u00e2nirea \u0219i obezitatea determin\u0103 adesea o sc\u0103dere a nivelurilor de NAD+, care joac\u0103 un rol esen\u021bial \u00een produc\u021bia de energie \u0219i \u00een metabolism. Studii anterioare efectuate pe animale au ar\u0103tat c\u0103 NMN poate cre\u0219te nivelurile de NAD+, contribuind la ameliorarea unor probleme metabolice precum rezisten\u021ba la insulin\u0103 \u0219i toleran\u021ba sc\u0103zut\u0103 la glucoz\u0103. Studiul pe care \u00eel analiz\u0103m este primul care exploreaz\u0103 modul \u00een care NMN afecteaz\u0103 metabolismul la om.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-how-the-researchers-conducted-the-study\">Cum au desf\u0103\u0219urat cercet\u0103torii studiul<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Cercet\u0103torii au realizat un studiu randomizat, dublu-orb, controlat cu placebo, care a durat 10 s\u0103pt\u0103m\u00e2ni. Au participat 25 de femei aflate \u00een postmenopauz\u0103, cu prediabet \u0219i un IMC cuprins \u00eentre 25,3 \u0219i 39,1. Ace\u0219tia au \u00eemp\u0103r\u021bit participantele \u00een dou\u0103 grupuri: <\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Grupul NMN<\/strong>: Am luat 250 mg de NMN zilnic, timp de 10 s\u0103pt\u0103m\u00e2ni. <\/li>\n\n\n\n<li><strong>Grupul placebo<\/strong>: A luat zilnic un placebo timp de 10 s\u0103pt\u0103m\u00e2ni. <\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-what-was-measured\">Ce s-a m\u0103surat<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\"> La \u00eenceputul \u0219i la sf\u00e2r\u0219itul studiului, cercet\u0103torii au m\u0103surat:<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u2022 Modific\u0103ri la nivelul celulelor musculare<\/strong>: Probele de \u021besut muscular au fost analizate pentru a identifica eventualele diferen\u021be la nivelul func\u021biei celulare.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u2022 Gr\u0103simea corporal\u0103 \u0219i masa muscular\u0103<\/strong>: Pentru a afla dac\u0103 s-au schimbat compozi\u021bia corporal\u0103.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u2022 Sensibilitatea la insulin\u0103<\/strong>: Evaluarea s-a realizat cu ajutorul unui test de clamp hiperinsulinemic-euglicemic pentru a determina c\u00e2t de bine a r\u0103spuns organismul la insulin\u0103.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-the-results-of-the-study\">Rezultatele studiului<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u2022 Metaboli\u021bii NAD+ \u0219i NMN<\/strong>: Grupul de femei care au luat NMN a prezentat o cre\u0219tere a nivelurilor de NAD+ \u00een celulele sanguine \u0219i a metaboli\u021bilor asocia\u021bi cu metabolismul NAD+ \u00een mu\u0219chi. Grupul care a primit placebo nu a prezentat nicio schimbare.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Sensibilitatea la insulin\u0103<\/strong>: Grupul tratat cu NMN a \u00eenregistrat o \u00eembun\u0103t\u0103\u021bire semnificativ\u0103 a sensibilit\u0103\u021bii musculare la insulin\u0103, cu o cre\u0219tere de 25% fa\u021b\u0103 de valorile ini\u021biale. Nu s-au observat modific\u0103ri ale sensibilit\u0103\u021bii la insulin\u0103 la nivelul ficatului sau al \u021besutului adipos. Grupul tratat cu placebo nu a prezentat modific\u0103ri.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u2022<\/strong> <strong>Expresia genic\u0103<\/strong>: NMN a crescut semnificativ num\u0103rul genelor active \u00een timpul perfuziei cu insulin\u0103 (308 de gene \u00een grupul NMN, comparativ cu doar 5 \u00een grupul placebo). Cercet\u0103torii au constatat c\u0103 aceste gene erau asociate \u00een principal cu repararea \u0219i regenerarea \u021besuturilor.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u2022<\/strong> <strong>Nu s-au \u00eenregistrat modific\u0103ri ale greut\u0103\u021bii corporale sau ale compozi\u021biei corporale<\/strong>: Nu s-au \u00eenregistrat modific\u0103ri semnificative ale greut\u0103\u021bii corporale, ale masei grase sau ale masei musculare \u00een niciunul dintre grupuri dup\u0103 10 s\u0103pt\u0103m\u00e2ni de tratament.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u2022<\/strong> <strong>Siguran\u021b\u0103<\/strong>: Cercet\u0103torii nu au semnalat efecte secundare, iar toate analizele de s\u00e2nge de rutin\u0103 au \u00eenregistrat valori normale.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-implications-of-the-results\">Implica\u021biile rezultatelor<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Acesta este primul studiu clinic care arat\u0103 c\u0103 NMN poate \u00eembun\u0103t\u0103\u021bi sensibilitatea la insulin\u0103 la oameni. Rezultatele subliniaz\u0103 poten\u021bialul NMN ca tratament specific pentru tulbur\u0103rile metabolice legate de v\u00e2rst\u0103 \u0219i prediabet, \u00een special \u00een cazul femeilor aflate \u00een postmenopauz\u0103, care prezint\u0103 adesea un risc mai ridicat de a dezvolta aceste afec\u021biuni.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Studiul arat\u0103 c\u0103 NMN poate juca un rol important \u00een \u00eembun\u0103t\u0103\u021birea func\u021biei musculare, prin optimizarea regl\u0103rii glicemiei \u0219i stimularea regener\u0103rii \u021besuturilor. Acest lucru poate contribui la prevenirea diabetului de tip 2 \u0219i la reducerea complica\u021biilor pe termen lung asociate cu rezisten\u021ba la insulin\u0103.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Rezultatele pozitive, al\u0103turi de un profil de siguran\u021b\u0103 solid \u0219i lipsa efectelor secundare, fac din NMN un candidat promi\u021b\u0103tor pentru cercet\u0103ri ulterioare. Studiile viitoare ar putea analiza dac\u0103 NMN are efecte benefice \u0219i asupra altor \u021besuturi, precum ficatul \u0219i \u021besutul adipos, \u0219i ar putea explora dac\u0103 duratele mai lungi de tratament \u0219i dozele mai mari ar putea amplifica efectele sale.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Acest lucru deschide calea c\u0103tre noi abord\u0103ri \u00een gestionarea bolilor metabolice \u0219i ofer\u0103 speran\u021ba c\u0103 NMN ar putea contribui la o \u00eemb\u0103tr\u00e2nire s\u0103n\u0103toas\u0103 \u0219i la \u00eembun\u0103t\u0103\u021birea calit\u0103\u021bii vie\u021bii.<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-other-results-on-the-muscle-function-with-nmn\">Alte rezultate privind func\u021bia muscular\u0103 cu NMN<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">A <a href=\"https:\/\/www.researchsquare.com\/article\/rs-455083\/v1\">studiu<\/a> Un studiu realizat de Universitatea din Tokyo \u00een 2022 a analizat efectele administr\u0103rii zilnice a unei doze de 250 mg de NMN, timp de 12 s\u0103pt\u0103m\u00e2ni, la b\u0103rba\u021bi cu v\u00e2rsta de 65 de ani \u0219i peste. Rezultatele au ar\u0103tat c\u0103 NMN a sporit semnificativ for\u021ba muscular\u0103, \u00eembun\u0103t\u0103\u021bind for\u021ba de prindere, viteza de mers \u0219i capacitatea de a se ridica de pe un scaun \u00een mai pu\u021bin de 30 de secunde. Cercet\u0103torii au constatat c\u0103 suplimentul este bine tolerat \u0219i sigur.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Cite\u0219te articolul complet aici: <a href=\"https:\/\/purovitalis.com\/ro\/suplimentele-nmn-imbunatatesc-functiile-musculare\/\">Suplimentele cu NMN \u00eembun\u0103t\u0103\u021besc func\u021biile musculare.<\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-more-positive-results-on-insulin-sensitivity-with-nmn\">Rezultate mai bune privind sensibilitatea la insulin\u0103 cu NMN<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Un recent <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/39185644\/\">recenzie<\/a> Rezultatele mai multor studii confirm\u0103 beneficiile NMN pentru func\u021bia muscular\u0103, s\u0103n\u0103tatea ficatului \u0219i sensibilitatea la insulin\u0103 la adul\u021bii \u00een v\u00e2rst\u0103. Suplimentarea cu NMN a \u00eembun\u0103t\u0103\u021bit viteza de mers cu p\u00e2n\u0103 la 20% \u0219i a stimulat func\u021bia hepatic\u0103 prin reducerea nivelului unor enzime cheie cu 15%. Studiul a ar\u0103tat, de asemenea, c\u0103 NMN a \u00eembun\u0103t\u0103\u021bit sensibilitatea la insulin\u0103 cu 8-10%, ceea ce ar putea reduce riscul de a dezvolta diabet. Cercet\u0103torii au constatat c\u0103 suplimentul este bine tolerat, nefiind raportate efecte secundare grave. Aceste descoperiri eviden\u021biaz\u0103 rolul NMN \u00een sus\u021binerea for\u021bei musculare, a s\u0103n\u0103t\u0103\u021bii metabolice \u0219i a vitalit\u0103\u021bii generale.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Cite\u0219te articolul complet aici: <a href=\"https:\/\/purovitalis.com\/ro\/revizuirea-studiilor-nmn\/\">Analiz\u0103 a studiilor efectuate pe oameni privind NMN: beneficii pentru s\u0103n\u0103tatea mu\u0219chilor \u0219i a ficatului.<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Te-ar mai putea interesa \u0219i urm\u0103toarele: <a href=\"https:\/\/purovitalis.com\/ro\/glucose-goddess-hacks-pentru-stabilizarea-zaharului-din-sange\/\">Sfaturi de la \u201eZei\u021ba Glucozei\u201d: Cum s\u0103-\u021bi controlezi glicemia pentru s\u0103n\u0103tate \u0219i longevitate<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Referin\u021b\u0103: <\/strong><br>1. Yoshino, M., Yoshino, J., Kayser, B. D., Patti, G. J., Franczyk, M. P., Mills, K. F., Sindelar, M., Pietka, T., Patterson, B. W., Imai, S.-I. \u0219i Klein, S. (2021). <strong>Mononucleotida de nicotinamid\u0103 cre\u0219te sensibilitatea muscular\u0103 la insulin\u0103 la femeile \u00een stadiu prediabetic.<\/strong> <em>Science, 372<\/em>(6547), 1224\u20131229. <a>https:\/\/doi.org\/10.1126\/science.abe9985<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">2. Wang, J.-P., Wang, L., Wang, T., Zhang, Y.-D., Zhou, A.-J., Wang, Z.-P. \u0219i Xiong, Z.-E. (2024). Efectele supliment\u0103rii cu mononucleotid\u0103 de nicotinamid\u0103 asupra func\u021biilor musculare \u0219i hepatice la persoanele de v\u00e2rst\u0103 mijlocie \u0219i v\u00e2rstnici. O revizuire sistematic\u0103 \u0219i o metaanaliz\u0103 a studiilor clinice randomizate controlate. <em>Biotehnologia farmaceutic\u0103 actual\u0103<\/em>. <a>https:\/\/doi.org\/10.2174\/0113892010306242240808094303<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">3: Igarashi, M., Miura, M., Nakagawa-Nagahama, Y., Yaku, K. \u0219i al\u021bi 12 autori. (2024). Suplimentarea cronic\u0103 cu mononucleotid\u0103 de nicotinamid\u0103 cre\u0219te nivelurile de nicotinamid\u0103-adenin\u0103-dinucleotid\u0103 din s\u00e2nge \u0219i modific\u0103 motilitatea muscular\u0103 la b\u0103rba\u021bii v\u00e2rstnici s\u0103n\u0103to\u0219i. <em>Preprint<\/em>. <a href=\"https:\/\/doi.org\/10.21203\/rs.3.rs-455083\/v1\">https:\/\/doi.org\/10.21203\/rs.3.rs-455083\/v1<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>","protected":false},"excerpt":{"rendered":"<p>How can NMN contribute to better metabolic health? A research team from Washington University School of Medicine in St. Louis investigated this topic in a clinical study published in the journal Science. The study focuses on NMN\u2019s potential to improve metabolism in postmenopausal women aged 55 to 75 with prediabetes. Background of the study Aging [&hellip;]<\/p>\n","protected":false},"author":6,"featured_media":136768,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[68],"tags":[355,168],"class_list":["post-136724","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-science","tag-balance","tag-nmn"],"acf":[],"_links":{"self":[{"href":"https:\/\/purovitalis.com\/ro\/wp-json\/wp\/v2\/posts\/136724","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/purovitalis.com\/ro\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/purovitalis.com\/ro\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/purovitalis.com\/ro\/wp-json\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/purovitalis.com\/ro\/wp-json\/wp\/v2\/comments?post=136724"}],"version-history":[{"count":5,"href":"https:\/\/purovitalis.com\/ro\/wp-json\/wp\/v2\/posts\/136724\/revisions"}],"predecessor-version":[{"id":152515,"href":"https:\/\/purovitalis.com\/ro\/wp-json\/wp\/v2\/posts\/136724\/revisions\/152515"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/purovitalis.com\/ro\/wp-json\/wp\/v2\/media\/136768"}],"wp:attachment":[{"href":"https:\/\/purovitalis.com\/ro\/wp-json\/wp\/v2\/media?parent=136724"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/purovitalis.com\/ro\/wp-json\/wp\/v2\/categories?post=136724"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/purovitalis.com\/ro\/wp-json\/wp\/v2\/tags?post=136724"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}