{"id":170,"date":"2022-12-15T08:17:00","date_gmt":"2022-12-15T07:17:00","guid":{"rendered":"https:\/\/purovitalis.com\/index.php\/2023\/05\/03\/fitter-younger-healthier-a-compelling-human-trial-on-nmn-supplementation\/"},"modified":"2025-08-28T11:18:20","modified_gmt":"2025-08-28T10:18:20","slug":"studiu-convingator-pe-oameni-privind-eficacitatea-nmn","status":"publish","type":"post","link":"https:\/\/purovitalis.com\/ro\/compelling-human-trial-on-nmn-efficacy\/","title":{"rendered":"Studiu: Eficacitatea \u0219i siguran\u021ba supliment\u0103rii cu NMN la adul\u021bii s\u0103n\u0103to\u0219i de v\u00e2rst\u0103 mijlocie"},"content":{"rendered":"<div class=\"taxonomy-post_tag blog-tags wp-block-post-terms\"><a href=\"https:\/\/purovitalis.com\/ro\/tag\/longevity\/\" rel=\"tag\">longevitate<\/a><span class=\"wp-block-post-terms__separator\"> <\/span><a href=\"https:\/\/purovitalis.com\/ro\/tag\/nmn\/\" rel=\"tag\">Nmn<\/a><\/div>\n\n\n<div class=\"wp-block-group blog-table-of-contents\"><div class=\"wp-block-group__inner-container is-layout-constrained wp-block-group-is-layout-constrained\">\n<p class=\"wp-block-paragraph\">cuprins<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><a href=\"#h-purpose-of-the-study\">Scopul studiului<\/a><\/li>\n\n\n\n<li><a href=\"#h-how-the-study-was-conducted\">Cum s-a desf\u0103\u0219urat studiul<\/a><\/li>\n\n\n\n<li><a href=\"#h-assessments-and-tests-conducted\">Evalu\u0103ri \u0219i teste efectuate<\/a><\/li>\n\n\n\n<li><a href=\"#h-summary-of-clinical-findings\">Rezumatul rezultatelor clinice<\/a><\/li>\n<\/ul>\n<\/div><\/div>\n\n\n\n<p class=\"wp-block-paragraph\">De peste un deceniu, NMN este \u00een centrul aten\u021biei \u0219tiin\u021bifice datorit\u0103 rolului s\u0103u \u00een sus\u021binerea produc\u021biei de energie celular\u0103 \u0219i men\u021binerea nivelurilor de NAD\u207a \u2014 un factor cheie pentru s\u0103n\u0103tatea metabolic\u0103 \u0219i \u00eemb\u0103tr\u00e2nire.<br>Studiile pe animale au ar\u0103tat constant efecte promi\u021b\u0103toare: rezisten\u021b\u0103 mai bun\u0103, func\u021bie mitocondrial\u0103 \u00eembun\u0103t\u0103\u021bit\u0103 \u0219i semne de \u00eencetinire a \u00eemb\u0103tr\u00e2nirii biologice.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Cu toate acestea, multe dintre afirma\u021biile privind efectele NMN asupra oamenilor s-au bazat p\u00e2n\u0103 \u00een prezent pe date preclinice. Acest lucru a dat na\u0219tere unor critici, \u00een special din cauza lipsei dovezilor clinice privind eficacitatea sa \u0219i \u2014 la fel de important \u2014 siguran\u021ba sa la persoanele s\u0103n\u0103toase.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Aceast\u0103 incertitudine pare s\u0103 fi fost acum clarificat\u0103. Un nou studiu clinic randomizat, controlat cu placebo, a analizat at\u00e2t eficacitatea, c\u00e2t \u0219i siguran\u021ba supliment\u0103rii cu NMN la adul\u021bi s\u0103n\u0103to\u0219i de v\u00e2rst\u0103 mijlocie \u2014 iar rezultatele ofer\u0103 perspective noi asupra rolului poten\u021bial al acestuia \u00een s\u0103n\u0103tatea uman\u0103, energia \u0219i longevitatea.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-purpose-of-the-study\">Scopul studiului<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Cercet\u0103tori din SUA, China, \u021a\u0103rile de Jos \u0219i India au desf\u0103\u0219urat un studiu clinic pe oameni pentru a testa eficacitatea NMN. Rezultatele au fost publicate \u00een revista GeroScience \u00een decembrie 2022.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Acesta <a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC9735188\/\">studiu<\/a> se intitula: <em>Eficacitatea \u0219i siguran\u021ba supliment\u0103rii cu mononucleotid\u0103 de \u03b2-nicotinamid\u0103 (NMN) la adul\u021bii s\u0103n\u0103to\u0219i de v\u00e2rst\u0103 mijlocie: un studiu clinic randomizat, multicentric, dublu-orb, controlat cu placebo, cu grupuri paralele \u0219i dependent de doz\u0103<\/em>. <\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Acest studiu clinic a fost conceput pentru a evalua modul \u00een care suplimentarea cu NMN afecteaz\u0103 adul\u021bii s\u0103n\u0103to\u0219i afla\u021bi la v\u00e2rsta de mijloc. La studiu au participat \u00een total 80 de persoane cu v\u00e2rste cuprinse \u00eentre 40 \u0219i 65 de ani. Ace\u0219tia au fost repartiza\u021bi aleatoriu pentru a primi fie un placebo, fie o doz\u0103 zilnic\u0103 oral\u0103 de NMN \u2014 300 mg, 600 mg sau 900 mg \u2014 timp de 60 de zile.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Studiul a urmat un protocol riguros: a fost randomizat, dublu-orb \u0219i controlat cu placebo, ceea ce \u00eenseamn\u0103 c\u0103 nici participan\u021bii, nici cercet\u0103torii nu \u0219tiau cine a primit NMN \u0219i cine a primit placebo pe durata studiului.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Scopul principal al studiului a fost acela de a m\u0103sura modific\u0103rile nivelurilor de NAD\u207a din s\u00e2nge.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u00cen plus, cercet\u0103torii au evaluat mai multe rezultate secundare:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Siguran\u021ba \u0219i tolerabilitatea generale, pe baza analizelor de laborator \u0219i a efectelor secundare raportate<\/li>\n\n\n\n<li>Rezisten\u021ba fizic\u0103, m\u0103surat\u0103 cu ajutorul unui test de mers pe jos de 6 minute<\/li>\n\n\n\n<li>V\u00e2rsta biologic\u0103, estimat\u0103 pe baza unor biomarkeri din s\u00e2nge<\/li>\n\n\n\n<li>Calitatea vie\u021bii, evaluat\u0103 prin intermediul unui chestionar<\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-how-the-study-was-conducted\">Cum s-a desf\u0103\u0219urat studiul<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Acesta a fost un studiu clinic randomizat, dublu-orb, controlat cu placebo, cu grupuri paralele, dependent de doz\u0103 \u0219i multicentric \u2014 un design metodologic solid, utilizat frecvent \u00een cercetarea clinic\u0103 pentru a asigura rezultate fiabile \u0219i impar\u021biale.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Studiul a inclus 80 de adul\u021bi s\u0103n\u0103to\u0219i cu v\u00e2rste cuprinse \u00eentre 40 \u0219i 65 de ani. Participan\u021bii au fost \u00eemp\u0103r\u021bi\u021bi aleatoriu \u00een patru grupuri: trei grupuri care au primit NMN (300 mg, 600 mg \u0219i 900 mg) \u0219i un grup placebo. Fiecare participant a luat capsulele care i-au fost alocate o dat\u0103 pe zi, timp de 60 de zile, \u00eenainte de micul dejun.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Capsulele cu NMN con\u021bineau 150 mg de mononucleotid\u0103 de \u03b2-nicotinamid\u0103 pur\u0103. Capsulele placebo erau identice ca aspect \u0219i con\u021bineau 150 mg de f\u0103in\u0103 de orez.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"h-group-overview\">Prezentare general\u0103 a grupului<\/h3>\n\n\n\n<figure class=\"wp-block-table\"><table class=\"has-fixed-layout\"><thead><tr><th><strong>Grup<\/strong><\/th><th><strong>Aportul zilnic<\/strong><\/th><\/tr><\/thead><tbody><tr><td>Grupul placebo<\/td><td>2\u20136 capsule cu placebo (fiecare con\u021bin\u00e2nd 150 mg de f\u0103in\u0103 de orez)<\/td><\/tr><tr><td>300 mg NMN Group<\/td><td>2 \u00d7 150 mg NMN<\/td><\/tr><tr><td>600 mg NMN Group<\/td><td>4 \u00d7 150 mg NMN<\/td><\/tr><tr><td>900 mg NMN Group<\/td><td>6 \u00d7 150 mg NMN<\/td><\/tr><\/tbody><\/table><figcaption class=\"wp-element-caption\">20 de participan\u021bi pe grup, \u00een total 80 de participan\u021bi.<\/figcaption><\/figure>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"h-inclusion-and-exclusion-criteria\">Criterii de includere \u0219i de excludere<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">Participan\u021bii eligibili au fost adul\u021bi s\u0103n\u0103to\u0219i care se \u00eencadrau \u00een intervalul de v\u00e2rst\u0103 specificat. Criteriile de excludere au inclus consumul de suplimente pe baz\u0103 de NAD \u00eenainte de \u00eenceperea studiului, consumul actual de statine, fumatul, consumul abuziv recent de droguri sau alcool sau participarea la alte studii clinice.<br>Femeile \u00eens\u0103rcinate sau care al\u0103pteaz\u0103 au fost excluse, iar toate participantele au fost supuse unui test de sarcin\u0103 din urin\u0103 \u00eenainte de \u00eenscriere.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-assessments-and-tests-conducted\">Evalu\u0103ri \u0219i teste efectuate<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Participan\u021bii au fost repartiza\u021bi aleatoriu \u00een unul dintre cele patru grupuri \u00een ziua 0. M\u0103sur\u0103torile ini\u021biale au fost efectuate \u00eenainte de \u00eenceperea oric\u0103rei supliment\u0103ri. Evalu\u0103rile de urm\u0103rire au fost efectuate \u00een ziua 30 \u0219i \u00een ziua 60 pentru a evalua at\u00e2t eficacitatea, c\u00e2t \u0219i siguran\u021ba.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Iat\u0103 o prezentare general\u0103 a evalu\u0103rilor efectuate:<\/p>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"h-nad-concentration-in-the-blood\">Concentra\u021bia de NAD\u207a \u00een s\u00e2nge<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">Criteriul principal de evaluare a fost varia\u021bia nivelurilor de NAD\u207a din s\u00e2nge.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Pentru cuantificarea NAD\u207a \u0219i NADH totale din ser s-a utilizat un test colorimetric validat.<br>\u00cen toate grupurile tratate cu NMN s-au observat cre\u0219teri semnificative, dependente de doz\u0103, ale nivelurilor de NAD, at\u00e2t \u00een compara\u021bie cu valorile ini\u021biale, c\u00e2t \u0219i cu cele din grupul placebo. Probele de s\u00e2nge au fost recoltate \u00een ziua 0, \u00een ziua 30 \u0219i \u00een ziua 60.<\/p>\n\n\n\n<div class=\"wp-block-group blog-definition\"><div class=\"wp-block-group__inner-container is-layout-constrained wp-block-group-is-layout-constrained\">\n<p class=\"wp-block-paragraph\">Test colorimetric<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Un test colorimetric este o metod\u0103 de laborator care m\u0103soar\u0103 concentra\u021bia unei substan\u021be pe baza unei schimb\u0103ri de culoare. \u00cen acest studiu, testul a fost utilizat pentru a detecta nivelurile totale de NAD\u207a \u0219i NADH din serul sanguin. Cu c\u00e2t semnalul de culoare este mai intens, cu at\u00e2t concentra\u021bia este mai mare.<\/p>\n<\/div><\/div>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"h-safety-and-tolerability-of-nmn-supplementation\">Siguran\u021ba \u0219i tolerabilitatea supliment\u0103rii cu NMN<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">Unul dintre obiectivele secundare a fost evaluarea siguran\u021bei \u0219i a tolerabilit\u0103\u021bii supliment\u0103rii cu NMN.<br>\u00cen acest scop, cercet\u0103torii au efectuat analize de s\u00e2nge \u0219i urin\u0103, precum \u0219i examin\u0103ri fizice pe toat\u0103 durata studiului. Toate evenimentele adverse au fost \u00eenregistrate \u0219i monitorizate. Tolerabilitatea a fost evaluat\u0103 \u0219i prin urm\u0103rirea faptului dac\u0103 participan\u021bii au finalizat studiul \u2014 \u0219i, \u00een mod deosebit, nimeni din niciun grup nu a abandonat studiul.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"h-6-minute-walking-test\">Testul de mers pe jos de 6 minute<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">Testul de mers pe jos de 6 minute s-a efectuat \u00een zilele 0, 30 \u0219i 60 pentru a evalua rezisten\u021ba.<br>Participan\u021bii au fost instrui\u021bi s\u0103 mearg\u0103 pe jos c\u00e2t mai mult \u00een 6 minute, iar distan\u021ba total\u0103 parcurs\u0103 a fost \u00eenregistrat\u0103. Aceasta a constituit unul dintre indicatorii secundari pentru evaluarea efectului NMN asupra performan\u021bei fizice.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u00cenrudit: <a href=\"https:\/\/purovitalis.com\/ro\/nmn-imbunatateste-rezistenta-la-efort\/\">Studiu: Poate NMN s\u0103 te ajute s\u0103 ob\u021bii mai mult de la antrenamentul t\u0103u?<\/a><\/p>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"h-the-biological-age-test\">Testul v\u00e2rstei biologice <\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">V\u00e2rsta biologic\u0103 a participan\u021bilor a fost estimat\u0103 cu ajutorul aplica\u021biei Aging.Ai 3.0 \u2013 un instrument digital care calculeaz\u0103 v\u00e2rsta aparent\u0103 a organismului pe baza rezultatelor analizelor de s\u00e2nge.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Acesta utilizeaz\u0103 19 markeri sanguini obi\u0219nui\u021bi, printre care colesterolul, glicemia, proteinele, hemoleucograma, electroli\u021bii, precum \u0219i globulele ro\u0219ii \u0219i albe. M\u0103sur\u0103torile au fost efectuate la \u00eenceputul studiului (ziua 0) \u0219i la sf\u00e2r\u0219itul acestuia (ziua 60) pentru a vedea dac\u0103 NMN a avut vreun impact asupra semnelor de \u00eemb\u0103tr\u00e2nire ale organismului.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"h-homa-index\">Indicele HOMA<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">Aceasta este valoarea care conteaz\u0103 foarte mult \u00een ceea ce prive\u0219te rezisten\u021ba la insulin\u0103. Ea arat\u0103 c\u00e2t de bine poate s\u0103 mai ac\u021bioneze insulina \u00een organismul t\u0103u. Valorile cuprinse \u00eentre 0,8 \u0219i 1,4 sunt cele mai bune. Diabetul \u00eencepe de la o valoare de aproximativ 2,5.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"h-sf-36-questionnaire\">Chestionarul SF-36<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">Acest chestionar a fost conceput pentru a evalua calitatea vie\u021bii \u0219i starea general\u0103 de s\u0103n\u0103tate a participantului.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-summary-of-clinical-findings\">Rezumatul rezultatelor clinice<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Pe baza evalu\u0103rilor de mai sus, studiul clinic a reu\u0219it s\u0103 stabileasc\u0103 modul \u00een care diferite doze de suplimente cu NMN:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Influeaz\u0103 concentra\u021biile de NAD\u207a din s\u00e2nge<\/li>\n\n\n\n<li>Este tolerat de organismul uman<\/li>\n\n\n\n<li>Influeaz\u0103 rezisten\u021ba fizic\u0103<\/li>\n\n\n\n<li>Influeaz\u0103 v\u00e2rsta biologic\u0103<\/li>\n\n\n\n<li>Modific\u0103 rezisten\u021ba la insulin\u0103<\/li>\n\n\n\n<li>Are un impact asupra calit\u0103\u021bii vie\u021bii percepute \u0219i asupra st\u0103rii generale de s\u0103n\u0103tate<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n\n\n\n<figure class=\"wp-block-image\"><img loading=\"lazy\" decoding=\"async\" width=\"1500\" height=\"1552\" src=\"https:\/\/purovitalis.com\/wp-content\/uploads\/2023\/05\/efficacy-and-safety-of-\u03b2-nicotinamide-mononucleotide.webp\" alt=\"Eficacitatea grupului placebo \u0219i a celor trei grupuri tratate cu NMN, compara\u021bii \u00eentre cele trei grupuri tratate \u0219i grupul placebo, \u00eentre dozele de 600 mg \u0219i 300 mg, precum \u0219i \u00eentre dozele de 900 mg \u0219i 600 mg, \u00een ceea ce prive\u0219te modific\u0103rile eficacit\u0103\u021bii (\u0394medie \u00b1 SEM) de la momentul ini\u021bial p\u00e2n\u0103 \u00een ziua 30 \u0219i\/sau ziua 60.\" class=\"wp-image-1407\" srcset=\"https:\/\/purovitalis.com\/wp-content\/uploads\/2023\/05\/efficacy-and-safety-of-\u03b2-nicotinamide-mononucleotide.webp 1500w, https:\/\/purovitalis.com\/wp-content\/uploads\/2023\/05\/efficacy-and-safety-of-\u03b2-nicotinamide-mononucleotide-600x621.webp 600w, https:\/\/purovitalis.com\/wp-content\/uploads\/2023\/05\/efficacy-and-safety-of-\u03b2-nicotinamide-mononucleotide-290x300.webp 290w, https:\/\/purovitalis.com\/wp-content\/uploads\/2023\/05\/efficacy-and-safety-of-\u03b2-nicotinamide-mononucleotide-990x1024.webp 990w, https:\/\/purovitalis.com\/wp-content\/uploads\/2023\/05\/efficacy-and-safety-of-\u03b2-nicotinamide-mononucleotide-768x795.webp 768w, https:\/\/purovitalis.com\/wp-content\/uploads\/2023\/05\/efficacy-and-safety-of-\u03b2-nicotinamide-mononucleotide-1485x1536.webp 1485w, https:\/\/purovitalis.com\/wp-content\/uploads\/2023\/05\/efficacy-and-safety-of-\u03b2-nicotinamide-mononucleotide-60x62.webp 60w, https:\/\/purovitalis.com\/wp-content\/uploads\/2023\/05\/efficacy-and-safety-of-\u03b2-nicotinamide-mononucleotide-110x114.webp 110w, https:\/\/purovitalis.com\/wp-content\/uploads\/2023\/05\/efficacy-and-safety-of-\u03b2-nicotinamide-mononucleotide-32x32.webp 32w\" sizes=\"auto, (max-width: 1500px) 100vw, 1500px\" \/><figcaption class=\"wp-element-caption\"><span style=\"color: #333333; font-family: Georgia, Palatino, serif; font-size: 18px; font-weight: 400; background-color: #fcfcfc;\">Eficacitatea grupului placebo \u0219i a celor trei grupuri tratate cu NMN, compara\u021bii \u00eentre cele trei grupuri tratate \u0219i grupul placebo, \u00eentre dozele de 600 mg \u0219i 300 mg, precum \u0219i \u00eentre dozele de 900 mg \u0219i 600 mg, \u00een ceea ce prive\u0219te modific\u0103rile eficacit\u0103\u021bii (\u0394medie \u00b1 SEM) de la momentul ini\u021bial p\u00e2n\u0103 \u00een ziua 30 \u0219i\/sau ziua 60. Sursa imaginii: <a href=\"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11357-022-00705-1.pdf\">Springer<\/a>.<\/span><\/figcaption><\/figure>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"h-nad-levels-increased-significantly-in-all-nmn-groups\">Nivelurile de NAD\u207a au crescut semnificativ \u00een toate grupurile tratate cu NMN<\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Toate cele trei doze de NMN (300, 600 \u0219i 900 mg\/zi) au dus la cre\u0219teri semnificative din punct de vedere statistic ale nivelurilor de NAD\u207a din s\u00e2nge, comparativ cu valorile ini\u021biale \u0219i cu placebo.<\/li>\n<\/ul>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Cre\u0219terea a fost dependent\u0103 de doz\u0103, dar diferen\u021ba \u00eentre 600 mg \u0219i 900 mg a fost minim\u0103.<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"h-nmn-supplementation-appears-safe-and-well-tolerated\">Suplimentarea cu NMN pare s\u0103 fie sigur\u0103 \u0219i bine tolerat\u0103<\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Nu s-au constatat anomalii relevante din punct de vedere clinic \u00een niciunul dintre parametrii analizelor de s\u00e2nge sau de urin\u0103.<\/li>\n<\/ul>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Au fost raportate \u00een total 9 evenimente adverse (EA): 6 \u00een grupul placebo, 1 \u00een grupul care a primit 300 mg de NMN \u0219i 2 \u00een grupul care a primit 600 mg.<\/li>\n<\/ul>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Niciuna dintre reac\u021biile adverse nu a fost considerat\u0103 grav\u0103.<\/li>\n<\/ul>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Niciun eveniment advers nu a fost atribuit NMN.<br><\/li>\n\n\n\n<li>Niciun participant nu s-a retras din studiu.<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"h-walking-distance-improved-in-nmn-groups\">Distan\u021ba parcurs\u0103 pe jos s-a \u00eembun\u0103t\u0103\u021bit \u00een grupurile tratate cu NMN<\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u00cen grupul placebo nu s-a observat nicio schimbare semnificativ\u0103 \u00een ceea ce prive\u0219te distan\u021ba parcurs\u0103 pe jos.<\/li>\n\n\n\n<li>Toate grupurile care au luat NMN au \u00eenregistrat \u00eembun\u0103t\u0103\u021biri semnificative la testul de mers pe jos de 6 minute p\u00e2n\u0103 \u00een ziua 60, comparativ cu grupul placebo.<\/li>\n\n\n\n<li>Grupul care a primit 600 mg a fost mai bun dec\u00e2t cel care a primit 300 mg, dar nu s-a v\u0103zut nicio diferen\u021b\u0103 important\u0103 \u00eentre grupurile de 600 mg \u0219i 900 mg. <br><br> Poate vrei s\u0103 cite\u0219ti \u0219i: <a title=\"Suplimentele cu NMN \u00eembun\u0103t\u0103\u021besc func\u021biile musculare\" href=\"\/ro\/suplimentele-nmn-imbunatatesc-functiile-musculare\/\">Studiu: NMN ar putea \u00eembun\u0103t\u0103\u021bi func\u021bia muscular\u0103<\/a>.<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"h-biological-age-decreased-in-nmn-groups\">V\u00e2rsta biologic\u0103 a sc\u0103zut \u00een grupurile NMN<\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u00cen ziua 60, v\u00e2rsta biologic\u0103 a sc\u0103zut semnificativ \u00een toate grupurile tratate cu NMN, comparativ cu valorile ini\u021biale.<\/li>\n\n\n\n<li>\u00cen schimb, grupul placebo a \u00eenregistrat o cre\u0219tere semnificativ\u0103 a v\u00e2rstei biologice.<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"h-quality-of-life-scores-improved\">Scorurile privind calitatea vie\u021bii s-au \u00eembun\u0103t\u0103\u021bit<\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Toate grupurile tratate cu NMN au \u00eenregistrat \u00eembun\u0103t\u0103\u021biri semnificative din punct de vedere statistic \u00een ceea ce prive\u0219te scorurile ob\u021binute la chestionarul de s\u0103n\u0103tate SF-36 p\u00e2n\u0103 \u00een ziua 60.<\/li>\n\n\n\n<li>Nu s-au constatat diferen\u021be semnificative \u00eentre grupurile tratate cu NMN.<\/li>\n\n\n\n<li>Grupul placebo nu a prezentat nicio \u00eembun\u0103t\u0103\u021bire semnificativ\u0103.<\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-understanding-the-effects-of-nmn\">\u00cen\u021belegerea efectelor NMN<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Acest studiu clinic ofer\u0103 dovezi solide c\u0103 suplimentarea cu NMN este at\u00e2t sigur\u0103, c\u00e2t \u0219i eficient\u0103 pentru adul\u021bii s\u0103n\u0103to\u0219i de v\u00e2rst\u0103 mijlocie. Prin \u00eembun\u0103t\u0103\u021biri semnificative ale nivelurilor de NAD\u207a, ale rezisten\u021bei fizice, ale v\u00e2rstei biologice \u0219i ale calit\u0103\u021bii vie\u021bii, NMN demonstreaz\u0103 un poten\u021bial real ca parte a unei strategii de \u00eemb\u0103tr\u00e2nire s\u0103n\u0103toas\u0103.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Dac\u0103 e\u0219ti curios s\u0103 afli cum po\u021bi integra NMN \u00een rutina ta zilnic\u0103, arunc\u0103 o privire la <a href=\"https:\/\/purovitalis.com\/ro\/produse\/pulbere-nmn\/\">Suplimente cu NMN aici<\/a> \u2014 \u0219i simte diferen\u021ba pe care o poate face \u00een ceea ce prive\u0219te energia ta de zi cu zi.<\/p>\n\n\n\n<details class=\"wp-block-details blog-references is-layout-flow wp-block-details-is-layout-flow\"><summary>Referin\u021be <\/summary>\n<ol class=\"wp-block-list\">\n<li><strong>Yi L, Maier AB, Tao R, Lin Z, Vaidya A, Pendse S, Thasma S, Andhalkar N, Avhad G, Kumbhar V.<\/strong> Eficacitatea \u0219i siguran\u021ba supliment\u0103rii cu mononucleotid\u0103 de \u03b2-nicotinamid\u0103 (NMN) la adul\u021bii s\u0103n\u0103to\u0219i de v\u00e2rst\u0103 mijlocie: un studiu clinic randomizat, multicentric, dublu-orb, controlat cu placebo, cu grupuri paralele \u0219i dependent de doz\u0103 <em>GeroScience<\/em>. 8 decembrie 2022; 45(1):29\u201343. doi:10.1007\/s11357-022-00705-1. PMID: 36482258; PMCID: PMC9735188.<\/li>\n<\/ol>\n<\/details>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>","protected":false},"excerpt":{"rendered":"<p>table of contents For over a decade, NMN has been a focus of scientific interest due to its role in supporting cellular energy production and maintaining NAD\u207a levels \u2014 a key factor in metabolic health and aging.Animal studies have consistently shown promising effects: improved endurance, enhanced mitochondrial function, and signs of slowed biological aging. However, [&hellip;]<\/p>\n","protected":false},"author":6,"featured_media":241796,"comment_status":"closed","ping_status":"open","sticky":true,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[68],"tags":[177,168],"class_list":["post-170","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-science","tag-longevity","tag-nmn"],"acf":[],"_links":{"self":[{"href":"https:\/\/purovitalis.com\/ro\/wp-json\/wp\/v2\/posts\/170","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/purovitalis.com\/ro\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/purovitalis.com\/ro\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/purovitalis.com\/ro\/wp-json\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/purovitalis.com\/ro\/wp-json\/wp\/v2\/comments?post=170"}],"version-history":[{"count":5,"href":"https:\/\/purovitalis.com\/ro\/wp-json\/wp\/v2\/posts\/170\/revisions"}],"predecessor-version":[{"id":241748,"href":"https:\/\/purovitalis.com\/ro\/wp-json\/wp\/v2\/posts\/170\/revisions\/241748"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/purovitalis.com\/ro\/wp-json\/wp\/v2\/media\/241796"}],"wp:attachment":[{"href":"https:\/\/purovitalis.com\/ro\/wp-json\/wp\/v2\/media?parent=170"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/purovitalis.com\/ro\/wp-json\/wp\/v2\/categories?post=170"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/purovitalis.com\/ro\/wp-json\/wp\/v2\/tags?post=170"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}