{"id":175,"date":"2022-08-01T08:17:00","date_gmt":"2022-08-01T07:17:00","guid":{"rendered":"https:\/\/purovitalis.com\/index.php\/2023\/05\/03\/what-are-sirtuins\/"},"modified":"2025-06-27T14:02:16","modified_gmt":"2025-06-27T13:02:16","slug":"ce-sunt-sirtuinele","status":"publish","type":"post","link":"https:\/\/purovitalis.com\/ro\/what-are-sirtuins\/","title":{"rendered":"Ce sunt sirtuinele?"},"content":{"rendered":"

Dac\u0103 te-ai aplecat asupra suplimente pentru longevitate<\/a> Dac\u0103 te-ai interesat \u00een ultima vreme de NAD+ \u0219i NMN, probabil ai auzit \u0219i de sirtuine. Sirtuinele sunt o familie de \u0219apte proteine de semnalizare implicate \u00een numeroase procese metabolice. De\u0219i aceste proteine se g\u0103sesc \u00een nucleu, citoplasm\u0103 \u0219i mitocondrii ale celulelor umane, sirtuinele mitocondriale au fost \u00een mod special \u00een centrul aten\u021biei cercet\u0103torilor \u00een ultimii doi ani, datorit\u0103 rolului lor \u00een longevitate<\/a>.<\/p>\n\n\n\n

C\u00e2nd au fost descoperite sirtuinele?<\/h2>\n\n\n\n

Au fost descoperite pentru prima dat\u0103 \u00een anii 1970, c\u00e2nd cercet\u0103torii au constatat c\u0103 unele proteine de semnalizare regleaz\u0103 anumite p\u0103r\u021bi ale cromozomilor, \u0219i anume histonele (2)<\/a>. Histonele sunt proteine care dau suport structural cromozomilor \u0219i ac\u021bioneaz\u0103 ca ni\u0219te bobine \u00een jurul c\u0103rora se \u00eenf\u0103\u0219oar\u0103 ADN-ul. Cercet\u0103torii au descoperit c\u0103 acestea previn deteriorarea ADN-ului, favorizeaz\u0103 repararea acestuia \u0219i regleaz\u0103 ciclul celular (3)<\/a>.<\/p>\n\n\n\n

Func\u021biile sirtuinelor<\/h2>\n\n\n\n

\u00cen plus, sirtuinele regleaz\u0103 metabolismul energetic, rezisten\u021ba la stres, inflama\u021bia, ritmul circadian \u0219i func\u021bia neuronal\u0103 (4)<\/a>(5)<\/a>. \u00cens\u0103 cel mai important rol al sirtuinelor este acela de a determina c\u00e2t de repede vei \u00eemb\u0103tr\u00e2ni. Sirtuinele regleaz\u0103 \u00eenf\u0103\u0219urarea \u0219i desf\u0103\u0219urarea histonelor \u0219i controleaz\u0103 indirect ADN-ul care este \u00eenf\u0103\u0219urat \u00een jurul bobinei. Deoarece numai ADN-ul desf\u0103cut poate fi exprimat \u2014 procesul prin care informa\u021bia unui gen este utilizat\u0103 pentru a produce un produs util pentru organism \u2014 sirtuinele activeaz\u0103 sau dezactiveaz\u0103 genele care controleaz\u0103 \u00eemb\u0103tr\u00e2nirea \u0219i sporesc longevitatea.<\/p>\n\n\n\n

Cu toate acestea, ele au nevoie de NAD+ pentru a fi activate, iar NAD+ necesit\u0103 NMN \u0219i alte substraturi. Din p\u0103cate, nivelurile at\u00e2t ale NMN, c\u00e2t \u0219i ale NAD+ se pr\u0103bu\u0219e\u0219te \u00een pr\u0103pastie<\/a> Pe m\u0103sur\u0103 ce \u00eemb\u0103tr\u00e2nim, at\u00e2t de mult \u00eenc\u00e2t, odat\u0103 ce ajungem la 50 de ani, mai avem doar jum\u0103tate din cantitatea de NMN \u0219i NAD+ pe care o aveam la 20 de ani (9)<\/a>(10)<\/a>. Drept urmare, NMN, NAD+ \u0219i sirtuinele au c\u00e2\u0219tigat o mare popularitate \u00een medicina longevit\u0103\u021bii.<\/p>\n\n\n\n

Sirtuinele s-au impus ca o clas\u0103 important\u0103 de factori care regleaz\u0103 procesul de \u00eemb\u0103tr\u00e2nire, iar oamenii de \u0219tiin\u021b\u0103 au \u00eencercat s\u0103 \u00een\u021beleag\u0103 care sunt activatorii \u0219i inhibitorii acestora. Printre al\u021bii (cum ar fi NAD+), resveratrolul (un compus polifenolic) s-a eviden\u021biat, de asemenea, ca un activator puternic al sirtuinelor (11)<\/a>. \u00cen timp ce resveratrolul \u0219i NMN<\/a> se g\u0103sesc \u00een multe surse alimentare<\/a>, cantitatea lor este infim\u0103. A\u0219adar, consumul de suplimente este cea mai bun\u0103 modalitate de a men\u021bine un nivel s\u0103n\u0103tos al acestor substan\u021be chimice \u0219i proteine importante \u00een organism.<\/p>","protected":false},"excerpt":{"rendered":"

If you have been delving into longevity supplements like NAD+ and NMN lately, you must have heard about sirtuins. Sirtuins are a family of seven signalling proteins involved in several metabolic processes. While these proteins are found in the nucleus, cytoplasm, and mitochondria of human cells, mitochondrial sirtuins have especially been the focus of research […]<\/p>\n","protected":false},"author":6,"featured_media":15852,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[66],"tags":[174],"class_list":["post-175","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-longevity","tag-resveratrol"],"acf":[],"_links":{"self":[{"href":"https:\/\/purovitalis.com\/ro\/wp-json\/wp\/v2\/posts\/175","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/purovitalis.com\/ro\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/purovitalis.com\/ro\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/purovitalis.com\/ro\/wp-json\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/purovitalis.com\/ro\/wp-json\/wp\/v2\/comments?post=175"}],"version-history":[{"count":5,"href":"https:\/\/purovitalis.com\/ro\/wp-json\/wp\/v2\/posts\/175\/revisions"}],"predecessor-version":[{"id":242760,"href":"https:\/\/purovitalis.com\/ro\/wp-json\/wp\/v2\/posts\/175\/revisions\/242760"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/purovitalis.com\/ro\/wp-json\/wp\/v2\/media\/15852"}],"wp:attachment":[{"href":"https:\/\/purovitalis.com\/ro\/wp-json\/wp\/v2\/media?parent=175"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/purovitalis.com\/ro\/wp-json\/wp\/v2\/categories?post=175"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/purovitalis.com\/ro\/wp-json\/wp\/v2\/tags?post=175"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}