{"id":183,"date":"2022-09-01T08:17:00","date_gmt":"2022-09-01T07:17:00","guid":{"rendered":"https:\/\/purovitalis.com\/index.php\/2023\/05\/03\/nmn-supplements-to-prevent-liver-damage\/"},"modified":"2024-08-30T12:05:52","modified_gmt":"2024-08-30T11:05:52","slug":"suplimente-nmn-pentru-a-preveni-afectarea-ficatului","status":"publish","type":"post","link":"https:\/\/purovitalis.com\/ro\/nmn-supplements-to-prevent-liver-damage\/","title":{"rendered":"Studiu: Suplimentele cu NMN pentru prevenirea leziunilor hepatice"},"content":{"rendered":"<p class=\"wp-block-paragraph\">Consumul excesiv de alcool, combinat cu alte afec\u021biuni concomitente, poate duce la apari\u021bia mai multor stadii de afectare hepatic\u0103. Gravitatea \u0219i gama simptomelor depind de \u00eentinderea \u021besutului hepatic afectat de aceast\u0103 afec\u021biune. Studiile au ar\u0103tat rezultate promi\u021b\u0103toare \u00een ceea ce prive\u0219te capacitatea NMN de a reversa afectarea hepatic\u0103. Mai \u00eent\u00e2i, s\u0103 discut\u0103m \u00een ce stadii pot fi clasificate afec\u021biunile hepatice asociate consumului de alcool:<\/p>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"h-1-alcoholic-fatty-liver\">1. Steatoza hepatic\u0103 alcoolic\u0103<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">Hepatita gras\u0103 alcoolic\u0103 este prima \u0219i cea mai reversibil\u0103 form\u0103 de afectare hepatic\u0103 cauzat\u0103 de alcool. Consumul de alcool poate accentua acumularea de gr\u0103sime \u00een \u021besuturile hepatice. \u00cen acest stadiu, suplimentarea cu NMN prezint\u0103 cea mai mare eficacitate \u00een reducerea leziunilor hepatice cauzate de alcool.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"h-2-alcoholic-hepatitis\">2. Hepatita alcoolic\u0103<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">\u00cen aceast\u0103 etap\u0103, \u00eencepe s\u0103 apar\u0103 o inflama\u021bie acut\u0103 a celulelor hepatice, ceea ce reprezint\u0103 un semnal de alarm\u0103 privind apari\u021bia unor leziuni hepatice permanente dac\u0103 boala nu este tratat\u0103. Suplimentarea cu NMN \u00een aceast\u0103 etap\u0103 poate fi optim\u0103 \u00een asociere cu tratamentul medical, pentru a reduce inflama\u021bia \u0219i a preveni complica\u021biile permanente.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"h-3-alcoholic-liver-cirrhosis\">3. Ciroza hepatic\u0103 alcoolic\u0103<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">Ultima \u0219i cea mai complicat\u0103 etap\u0103 a afect\u0103rii ficatului este ciroza. \u00cen aceast\u0103 etap\u0103, \u021besuturile hepatice \u00ee\u0219i pierd complet func\u021bionalitatea \u0219i capacitatea de regenerare, put\u00e2nd fi tratate doar prin transplantul de \u021besuturi hepatice s\u0103n\u0103toase.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-liver-damage-and-nmn\">Leziunile hepatice \u0219i NMN<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">A <a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0891584920316269\">studiu<\/a> arat\u0103 c\u0103 <a title=\"Suplimente cu NMN \u0219i produse pentru cre\u0219terea nivelului de NAD de la Purovitalis\" href=\"\/ro\/produse\/nmn-capsule-lipozomale\/\">Supliment cu NMN<\/a> reduce acumularea de tioacetamid\u0103 (TAA) \u0219i tetraclorur\u0103 de carbon (CCl4) \u00een matricea extracelular\u0103 a ficatului, ace\u0219tia fiind doi compu\u0219i care induc fibroza hepatic\u0103 la \u0219oareci.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">De asemenea, NMN inhib\u0103 formarea celulelor stelate hepatice prin suprimarea degrad\u0103rii PGDH-15 mediate de oxidare.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Pe baza acestor rezultate, studiul sugereaz\u0103 c\u0103 suplimentarea cu NMN poate fi o nou\u0103 abordare terapeutic\u0103 care previne leziunile hepatice cauzate de fibroza hepatic\u0103.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-how-does-nmn-protect-against-liver-damage\">Cum te protejeaz\u0103 NMN \u00eempotriva leziunilor hepatice?<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">\u00cen bolile hepatice cauzate de alcool, metabolismul ficatului se deregleaz\u0103 semnificativ din cauza unei expresii genice perturbate. Consumul de alcool induce supraexpresia factorului de transcrip\u021bie activator 3, o protein\u0103 asociat\u0103 cu mai multe stadii ale leziunilor hepatice.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u00cen experimentul pe \u0219oareci, s-a v\u0103zut c\u0103 NMN reduce efectele deregl\u0103rii expresiei genelor asupra \u021besuturilor hepatice. Acest efect cre\u0219te \u00een stadiile incipiente ale consumului cronic de alcool.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-nmn-protects-against-liver-cirrhosis\">NMN protejeaz\u0103 \u00eempotriva cirozei hepatice<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">\u00cen cazul leziunilor hepatice acute sau cronice, reac\u021biile naturale de vindecare a leziunilor pot induce un proces de cicatrizare numit fibroz\u0103 hepatic\u0103. Progresia fibrozei hepatice poate duce la ciroz\u0103 hepatic\u0103 \u0219i, ulterior, la cancer hepatic.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Deoarece celulele stelate hepatice (HSC) sunt sursa principal\u0103 a matricei extracelulare care determin\u0103 progresia fibrozei hepatice, inhibarea acestor celule este cheia prevenirii cirozei hepatice.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Suplimentarea cu NMN <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/33220424\/\">este afi\u0219at<\/a> pentru a inhiba formarea de HSC, ceea ce este direct corelat cu reducerea riscului de progresie a fibrozei hepatice c\u0103tre ciroz\u0103.<\/p>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter\"><a href=\"\/ro\/produse\/nmn-capsule-lipozomale\/\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"282\" src=\"https:\/\/purovitalis.com\/wp-content\/uploads\/2023\/05\/product-banners-nmn-capsules_1024x1024.webp\" alt=\"\" class=\"wp-image-1099\" srcset=\"https:\/\/purovitalis.com\/wp-content\/uploads\/2023\/05\/product-banners-nmn-capsules_1024x1024.webp 1024w, https:\/\/purovitalis.com\/wp-content\/uploads\/2023\/05\/product-banners-nmn-capsules_1024x1024-600x165.webp 600w, https:\/\/purovitalis.com\/wp-content\/uploads\/2023\/05\/product-banners-nmn-capsules_1024x1024-300x83.webp 300w, https:\/\/purovitalis.com\/wp-content\/uploads\/2023\/05\/product-banners-nmn-capsules_1024x1024-768x212.webp 768w, https:\/\/purovitalis.com\/wp-content\/uploads\/2023\/05\/product-banners-nmn-capsules_1024x1024-60x17.webp 60w, https:\/\/purovitalis.com\/wp-content\/uploads\/2023\/05\/product-banners-nmn-capsules_1024x1024-110x30.webp 110w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/a><\/figure>\n<\/div>\n\n\n<h3 class=\"wp-block-heading\" id=\"h-references\">Referin\u021be<\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li><a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0891584920316269\">https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0891584920316269<\/a><\/li>\n<\/ul>","protected":false},"excerpt":{"rendered":"<p>Excess Alcohol consumption combined with other comorbidities can lead to several stages of liver damage. The severity and range of symptoms depend on the extent of the liver tissue affected by the condition. Study have shown promising results for NMN to revert liver damage. First let discuss where the stages of Alcohol-Related Liver disease can [&hellip;]<\/p>\n","protected":false},"author":6,"featured_media":15847,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[68],"tags":[168],"class_list":["post-183","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-science","tag-nmn"],"acf":[],"_links":{"self":[{"href":"https:\/\/purovitalis.com\/ro\/wp-json\/wp\/v2\/posts\/183","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/purovitalis.com\/ro\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/purovitalis.com\/ro\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/purovitalis.com\/ro\/wp-json\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/purovitalis.com\/ro\/wp-json\/wp\/v2\/comments?post=183"}],"version-history":[{"count":5,"href":"https:\/\/purovitalis.com\/ro\/wp-json\/wp\/v2\/posts\/183\/revisions"}],"predecessor-version":[{"id":60538,"href":"https:\/\/purovitalis.com\/ro\/wp-json\/wp\/v2\/posts\/183\/revisions\/60538"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/purovitalis.com\/ro\/wp-json\/wp\/v2\/media\/15847"}],"wp:attachment":[{"href":"https:\/\/purovitalis.com\/ro\/wp-json\/wp\/v2\/media?parent=183"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/purovitalis.com\/ro\/wp-json\/wp\/v2\/categories?post=183"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/purovitalis.com\/ro\/wp-json\/wp\/v2\/tags?post=183"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}