Study: NMN Extends Lifespan and Enhances Gut Health in Ageing Mice

Recent research on β-Nicotinamide Mononucleotide (NMN) supplementation reveals promising results for combating ageing. NMN, crucial for cellular energy, has been shown to extend the median lifespan of prematurely ageing mice by 20%. Additionally, NMN restored intestinal structural integrity in healthy, middle-aged mice. This study delves into NMN’s effects on lifespan and colon health, highlighting its potential benefits for ageing-related health issues.

Key Highlights

1. Lifespan Extension: NMN extended the lifespan of prematurely aged mice by 20%.
2. Microbiome Improvement: NMN increased beneficial bacteria like Akkermansia muciniphila which support a healthy digestive system.
3. Protein Expression: NMN helped balance levels of key proteins, including increasing SIRT1, NMNAT2 that are associated with ageing.

Study In-Depth Analysis

Lifespan Extension: NMN Extends Lifespan by 20%

In the study, mice, which are genetically modified to age prematurely, were given NMN to evaluate its impact on lifespan. These mice typically exhibit rapid ageing symptoms, leading to a shortened lifespan. NMN supplementation resulted in a significant extension of their lifespan by 20%. This effect is attributed to NMN’s role in enhancing cellular energy production and repair mechanisms, which are crucial for maintaining cellular health and function.

Furthermore, NMN was observed to reduce age-related physical decline in these mice. The treated mice displayed improved physical activity and overall health compared to untreated counterparts. This suggests that NMN not only extends lifespan but also improves the quality of life during ageing.

The study also monitored various biomarkers associated with ageing and found that NMN helped maintain more youthful levels of these markers. This included improvements in metabolic function and reduced markers of inflammation and oxidative stress, both of which are commonly associated with ageing. These results collectively support the hypothesis that NMN can mitigate the effects of rapid ageing and enhance longevity.

Related: Human Trial shows efficacy and safety of NMN

Gut Microbiome Improvements

The gut microbiome plays a crucial role in overall health. NMN increased the abundance of beneficial bacteria, particularly Akkermansia muciniphila and Bifidobacterium pseudolongum. These bacteria are known for their anti-inflammatory properties and their role in maintaining a healthy metabolic state. The increase in these beneficial bacteria can help improve digestion, reduce inflammation, and support a healthier immune response. This shift in the gut microbiome composition is indicative of a more balanced and resilient intestinal environment, which is essential for protecting against age-related gut dysfunctions.

Balancing Protein Levels

NMN helped balance proteins in the body that are associated with ageing. This includes increasing the levels of proteins that protect cells like SIRT1 and NMNAT2 and decreasing those that contribute to ageing like P53. By enhancing the levels of protective proteins, NMN supports cellular repair and maintenance processes. Conversely, by reducing the levels of proteins that can accelerate ageing, NMN helps to mitigate damage and stress within cells. This balanced protein regulation is crucial for maintaining cellular health and function over time, thereby contributing to overall longevity and vitality.

Colon Health

The colon undergoes significant changes with age, often leading to problems like increased permeability and inflammation. NMN supplementation improved the structure and function of the colon in ageing mice. This included better integrity of the intestinal barrier, more goblet cells (which produce protective mucus), and higher levels of anti-inflammatory factors. These changes contribute to a healthier colon environment, which is crucial for overall health.

Conclusion

The study demonstrates that NMN supplementation can significantly extend lifespan and improve colon health in ageing mice. By enhancing the integrity of the intestinal barrier, increasing beneficial bacteria, and modulating key proteins and metabolic pathways, NMN promotes a healthier, longer life. These findings suggest potential benefits of NMN for ageing-related health issues, particularly in maintaining gut health and overall vitality.

For detailed insights and data, you can access the full study here.

References

Gu Y, Gao L, He J, Luo M, Hu M, Lin Y, Li J, Hou T, Si J, Yu Y. β-Nicotinamide mononucleotide supplementation prolongs the lifespan of prematurely aged mice and protects colon function in ageing mice. Food Funct. 2024 Mar 6. doi: 10.1039/d3fo05221d. Epub ahead of print. PMID: 38445897.