NMN: A Potential Supplement for Age-Related Fertility

As more women choose to start families later in life, concerns about fertility have become increasingly important. Previous studies have already indicated that NMN (Nicotinamide Mononucleotide) can increase fertility in women.

You can read more about this in our detailed article on how NMN supplements may improve fertility in women here.

A brand new study from September 2024, published in Molecular and Cellular Oncology, has explored exactly that. The research focuses on NMN and its potential to reverse the effects of aging on ovarian function in mice. While it’s an animal study, the findings provide hope for future human research. There is potential that NMN could help address age-related fertility challenges in women and promote overall ovarian health.

Let’s break down the findings of the study in a clear and simple way.

Key Findings of the Study

The research conducted on aging mice revealed some fascinating insights into how NMN might help improve ovarian health:

1. Restoring NAD+ Levels: NAD+ levels in the ovaries decline with age, but NMN supplementation significantly restored these levels. NAD+ is crucial for energy production, directly impacting the health of ovarian cells, particularly the egg cells (oocytes).
   
2. Prevention of Ovarian Atrophy: With age, ovaries tend to shrink (atrophy), leading to fewer healthy oocytes. The study showed that NMN supplementation helped prevent this shrinkage, maintaining the size and structure of the ovaries. This suggests that NMN can support ovarian health by protecting against age-related degeneration.
   
3. Improvement in Oocyte Quality and Quantity: The number and quality of oocytes decrease with age, which is a major factor in reduced fertility. NMN was shown to improve both the number and quality of eggs in aging mice, which could have promising implications for fertility treatments in older women.
   
4. Reduced Inflammation and Oxidative Stress: NMN reduced inflammation and oxidative stress in the ovaries. Aging is often accompanied by chronic inflammation, which negatively affects reproductive health. By lowering these harmful factors, NMN helps create a healthier environment for the ovaries.
   
5. Hormonal Balance: The study observed an improvement in the secretion of important reproductive hormones, such as estrogen and follicle-stimulating hormone (FSH). Hormonal balance plays a critical role in maintaining healthy ovarian function.

What Does This Mean for Human Fertility?

Although this study was conducted on mice, it opens the door for exciting future research in humans. Age-related fertility decline is a growing concern with limited solutions. The findings suggest that NMN could provide a non-invasive way to support ovarian health and potentially slow the natural decline in fertility that comes with age. This gives hope that NMN may, with further research, become a valuable part of fertility treatments, especially for women facing age-related fertility challenges or those pursuing assisted reproductive technologies (ART), such as IVF.

For a deeper understanding of how age affects fertility, you might find our other blog post helpful: Women’s Age and Fertility: Reproductive Longevity and Health. It explores the natural decline of fertility with age and discusses strategies for managing these changes.

Purovitalis’ Approach to Premium NMN Supplementation

With the growing interest in NMN and its potential benefits, it’s important to choose a supplement that not only delivers NMN but does so in a way that maximizes its effectiveness. At Purovitalis, we’re committed to offering premium-quality NMN supplements. Our products use liposomal technology, which enhances absorption, ensuring that your body gets the most out of every dose.

If you’d like to learn more about NMN and its benefits, please visit our detailed guide here.

What’s Next for NMN and Fertility?

The next step will be human trials to confirm whether NMN can help improve ovarian health and fertility in women. If these trials are successful, NMN could become a vital part of treatments aimed at preserving fertility as women age.

Conclusion

This recent study on NMN’s effect on aging ovaries is a significant step toward understanding how we can support fertility and reproductive health as we age. While human studies are still needed, the results are promising, and NMN could offer a non-invasive way to maintain ovarian health and longevity, helping women preserve fertility for longer.

Another study you might be interested in is Spermidine for Fertility – Enhanced Egg Quality.

For more information on how NMN and other longevity supplements can support your health, explore our range of scientifically backed products at Purovitalis. Experience the benefits of liposomal technology and take the next step toward a healthier, longer life.

Reference:

Liang, J., Huang, F., Hao, X., Zhang, P., & Chen, R. (2024). Nicotinamide mononucleotide supplementation rescues mitochondrial and energy metabolism functions and ameliorates inflammatory states in the ovaries of aging mice. Metabolism Open. https://doi.org/10.1002/mco2.727

Please note: While these findings are promising, more research is needed to determine the effects of NMN on human fertility. Always consult with a healthcare professional before starting any new supplement regimen.