A recent study published in the journal Frontiers in Nutrition has investigated the effect of oral consumption of nicotinamide mononucleotide (NMN) on telomere length in older adults. Telomeres, the protective caps found at the end of chromosomes, play a crucial role in the aging process. The length of telomeres is a marker of cellular aging. As we age, the telomeres become shorter, leading to the deterioration of cells and the body’s ability to repair itself. The study found that oral consumption of NMN may have the potential to lengthen telomeres and slow the aging process.
NMN and Telomeres Lengthening
The study involved 30 older adults who were given a daily dose of 300 mg of NMN for 90 days. Telomere length was measured using a blood test at the beginning, in the middle and end of the study. The study found that the telomeres in the leukocytes (white blood cells) of participants who took NMN were, on average, 5% longer than those who did not take NMN.
Potential Mechanisms
The study did not figure out exactly how NMN can make telomeres longer. But it is shown that NMN can help boost the levels of NAD+, a coenzyme that is important for many cellular processes, including DNA repair. When we get older, NAD+ levels drop and this can cause telomeres to become shorter. Supplementing with NMN may help to increase NAD+ levels, which in turn may help to protect telomeres from shortening. More research is needed to understand how NMN affects telomere length.
Safety and Tolerance
The study also found that oral consumption of NMN was safe and well-tolerated. No serious adverse events were reported, and the majority of participants did not experience any side effects.
The Importance of Telomeres and Aging
As telomeres shorten with age, cells are less able to divide and repair themselves, leading to the deterioration of bodily functions and an increased risk of chronic diseases. By lengthening telomeres, it may be possible to slow the aging process and reduce the risk of chronic diseases associated with aging.
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Size and Limitations of the Study
Keep in mind that this study was only a pilot, a small initial study to check if an intervention is possible and get a rough idea of its impact. The sample size and length of the study is relatively short. More extensive and longer studies are required to confirm these results. Additionally, the study wasn’t randomised and controlled, more research is needed to back up these findings and look into the safety and effectiveness of oral NMN for telomere length in the long-term.
Conclusion
A study has found that oral consumption of NMN may have the potential to lengthen telomeres in older adults. Telomere length is a marker of cellular aging. And longer telomeres are thought to be associated with better health outcomes. Including a lower risk of chronic diseases such as cardiovascular disease and cancer. While the study is a small pilot study. It provides promising preliminary evidence that oral consumption of NMN can have a beneficial impact on telomere length. Which can contribute to better health outcomes in older adults. The findings of this study should be followed by larger, randomized controlled trials to confirm.
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References
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