Bryan Johnson Blueprint and Supplements Protocol | Purovitalis

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Bryan Johnson Blueprint and Supplements Protocol

Bryan Johnson, entrepreneur turned longevity enthusiast, engaging in his daily Blueprint anti-aging regimen, surrounded by various supplements and health-monitoring devices.

In this article:

Who is Bryan Johnson | Beginning of the Project | Daily Routine | Supplements List and Regime | Conclusion


Dive into the fascinating world of Bryan Johnson’s meticulously crafted anti-aging strategy with us! Explore the Bryan Johnson Blueprint, a comprehensive guide tailored towards decoding the secrets of longevity and vibrant health. Learn about the exhaustive Bryan Johnson Supplements protocol, a vital piece in his innovative approach towards a seemingly elusive goal: reversing the aging process. Our journey through this blog will unveil the intricate daily regimens, detailed supplement schedules, and the scientific backbone of Bryan’s commitment to pioneering in the field of anti-aging and longevity.

Who’s Bryan Johnson 

Bryan Johnson, the tech genius behind Venmo and Braintree, sold these companies for a whopping $800 million in 2013. In 2021, he kicked off Project Blueprint, a bold step towards reversing aging that has fascinated many globally.

Now a wealthy entrepreneur, 46-year-old Bryan has spent the past three years and over $4 million on a unique mission: avoiding death.

His solution is Blueprint, a life-extension system where 30 doctors make all decisions about his body. Their aim is to extend his life and reduce his ‘biological age’ by focusing on every aspect of his lifestyle. This thorough plan, using the newest technologies and costing about $2 million annually, supports Bryan’s ambitious goal without leaving any stone unturned.

Bryan Johnson’s Blueprint Project: The Beginning

Embark on a journey through Bryan Johnson’s Blueprint Project – more than a project, it’s a lifestyle, meticulously crafted from countless measurements and comprehensive body analyses. The heart of the project pulsates within the protocols, ceaselessly optimized by his medical team.

“When I go to bed from the moment I wake up, my entire life is structured around the system” Bryan shares.

Bryan also explored six-month, 1-liter plasma transfusions with his son, halting due to insufficient benefits and potential risks.

The Blueprint Project intertwines a stringent daily diet, a relentless workout regimen, and systematic organ-to-organ measurements, encapsulating Bryan’s daily existence

The Daily Routine

Welcome to a day in the life of Bryan Johnson, who plans every minute to fight getting older. His day starts early at 4:53 a.m., stepping on a scale and turning on a special light for 2-3 minutes to wake up his body.

Next, he checks his ear temperature and takes two iron pills with vitamin C. Moving forward, he focuses on his skin, using a laser light mask for five minutes to keep it healthy and clear.

By 6 a.m., Bryan is ready to start the rest of his day downstairs. After eating, he exercises to strengthen his grip and spends an hour working out, a tough routine he does every single day. Three days a week, these workouts are even harder, all part of his dedication to staying healthy and young-looking.

The Morning Routine

Medical Measurements

Bryan Johnson’s Blueprint emphasizes regular health checks. Weight, body fat, and body water are measured consistently. Blood glucose levels and MRI cancer screenings are also vital. Additionally, he ensures his veins, prostate, and thyroid are checked. A team of 30 doctors carefully watches these measurements.


Testing helps keep track of Bryan’s Blueprint results. The team uses MRI scans and ultrasound checks to spot and track potential diseases. Bryan shares details like his use of a Polar H10 Heart Rate Monitor Chest Strap on his website. It tracks his max heart rate and monitors how much his “age” reduces based on heart performance. With an aging pace of 0.69, Bryan shows his methods work, aging just 277 days per year. You can also compare your actual to biological age using the EpiAge Biological Age Test on our website. Bryan and his team regularly update the Blueprint website with these results.

The Diet

Bryan Johnson doesn’t use typical meal names. Instead, he says “first meal,” “second meal,” etc. Each meal is 100% vegan, with a daily caloric intake of 1977. The first meal, before his workout, features the “Green Giant” beverage, brimming with various supplements, paired with his initial supplement intake. For the second meal, the “Super Veggie” melds lentils, veggies, and a symphony of seasonings into a nutritious blend.The third meal varies, offering dishes like Asparagus Almond Beet Salad or Stuffed Sweet Potatoes.

Bryan Johnson Supplements List and Regime 

Bryan Johnson navigates through his day with a meticulous supplement routine, involving an array of 111 different items, each chosen with utmost precision. These are administered at carefully calculated intervals throughout his day, ensuring optimal absorption and efficacy. His day begins with a substantial dosage in the early morning, followed by a secondary intake at 11 a.m., curiously dubbed his ‘dinner’ time. Melatonin punctuates his regime just before bedtime, fostering restful sleep, while other supplements are sprinkled throughout his daily schedule.

Bryan’s selection spans a wide spectrum, carefully cherry-picked to support various aspects of his health and wellness, contributing to the efficacy of his Blueprint protocol. These supplements encompass vitamins, minerals, antioxidants, and other compounds, each playing a pivotal role in bolstering his bodily functions, fortifying immunity, enhancing cellular health, and supporting metabolic processes, among others. Whether it’s supporting his cognitive function, safeguarding his joints, or reinforcing his cardiovascular health, every supplement in Bryan’s regime has a distinct role, purposefully included to fortify his comprehensive approach to curbing the aging process.

Why Bryan Johnson Takes 100+ Pills Every Day

What Supplements Does Bryan Johnson Take?


Bryan Johnson includes Rapamycin in his supplement regimen. Originally discovered in Easter Island soil, this natural compound initially helped prevent body rejection of transplanted organs. Subsequent research revealed additional benefits.

Is consider a proper anti-age medication, since it can prevent life-limiting age-related diseases that could shorten a person’s life. 

This compound slows down mTOR proteins and it activates autophagy, bringing various health benefits like detoxification, cell renewal, and revitalization. 


Calcium Alpha-ketoglutarate (Ca-AKG), a calcium salt, has captured the longevity community’s attention. Used in a mouse study, it demonstrated potential to extend lifespan, delay aging conditions, reduce frailty, and mitigate chronic inflammation.

Hyaluronic Acid

This compound brings important benefits, It is a key component of connective tissues, skin, and the fluid that lubricates joints. 

Hyaluronic acid typically receives well tolerance and most consider it safe in appropriate doses. It’s a crucial component in many skincare and medical products thanks to its hydrating and tissue-supportive properties.

B Complex

This vitamins booster includes thiamine (B1), Riboflavin-5-phosphate (B2), Niacinamide (flush free Niacin – B3), Calcium D-pantothenate (B5), D-Biotin (B7) & Pyridoxal-5-Phosphate (Vit B6).

The body instantly absorbs this methylated vitamin form, enhancing energy metabolism, homocysteine regulation, nutrient metabolism, heart function, and neurological health.

Our Spermidine supplement include a your daily dose of Vitamin B complex

Vitamin D3

Vitamin D3 is essential to maintain bones strong, since it’s normally obtained from the diet or by sunlight energy. Also, Vitamin D It’s a powerful immune system booster and plays an important role in protecting us from seasonal diseases.

You can also try Purovitalis Vitamin D3, produced with Liposomal technology to boost your body absorption.

NAD Precursors

Nicotinamide riboside (NR) is a form of vitamin B3 and a precursor to nicotinamide adenine dinucleotide (NAD+), a coenzyme involved in various cellular processes, including metabolism and DNA repair.

Another powerful NAD+ precursor is NMNnicotinamide mononucleotide (NMN).


Bryan Johnson strategically includes Spermidine in his diet, especially for its role in autophagy, the body’s way of cleaning out damaged cells, and regenerating newer, healthier cells. Featured prominently in his “Green Giant” beverage during the first meal, Spermidine supports Bryan’s keen pursuit of cellular renewal and overall vitality, aligning with his thorough anti-aging strategy.


Bryan Johnson’s Supplements list also includes zinc, an important mineral for the body that works to support our natural defense system, directly linked to the immune system.

Bryan Johnson Blueprint Conclusion

He insists all this is about something much bigger than getting ripped and maintaining a youthful glow. “Most people assume death is inevitable. We’re just basically trying to prolong the time we have before we die,” he says. 

He adds, “I don’t think there’s been any time in history where Homo sapiens could say with a straight face that death may not be inevitable.”

Experts strongly disagree. “Death is not optional; it’s written into our genes,”says Dr. Pinchas Cohen, dean of the Leonard Davis School of Gerontology at the University of Southern California.

Cohen emphasizes that living longer in the future is certainly possible: over the course of the 20th century, human life expectancy rose from around 50 to more than 80. But living forever is not.

In conclusion, Bryan Johnson’s Blueprint program innovatively approaches reversing aging. While offering potential longevity benefits, it prompts ethical questions about the value of such eternal commitment.

You may also find it interesting to read: David Sinclair’s Supplement Regime

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